Manolis Kellis is a professor of Computer Science at the Massachusetts Institute of Technology. He works in computational biology, taking giant datasets relating to genetics and health outcomes and tries to understand what’s going on.
Manolis’ research focuses on genomics, and a related field called epigenomics. Manolis’ problem is this: What are the cellular mechanisms of a disease? And how can we intervene to keep people healthy? See omnystudio.com/listener for privacy information.

Understanding Obesity and Alzheimer’s via Epigenomics

Every week on What’s Your Problem, entrepreneurs and engineers talk about the future they’re trying to build – and the problems they have to solve to get there.

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Robert Langer has co-founded dozens of companies, holds over a thousand patents, and is a pioneering figure in drug delivery and tissue engineering. Robert has solved a lot of problems, and is working on many more with his lab at MIT. But there is one big problem that has stuck with Robert his whole career: How do you get discoveries out of the lab and into the world? See omnystudio.com/listener for privacy information.

How to Start 40 Companies (and Counting)

Mateo Jaramillo is the co-founder and CEO of Form Energy. Mateo’s problem is this: How do you build batteries that can provide affordable backup power to the grid for days at a time? As it turns out, the basic technology was developed – and then mostly ignored – over 50 years ago. See omnystudio.com/listener for privacy information.

The Cutting Edge of Energy Storage: Rust

This March, doctors successfully transplanted a pig kidney into a person for the first time in history. Mike Curtis is the CEO of eGenesis, the company that raised the pig whose kidney was used for the procedure. Mike's problem is this: How do you genetically engineer pigs to provide organs – kidneys, hearts, livers – for people? See omnystudio.com/listener for privacy information.

The First Pig to Human Kidney Transplant

Imagine picking up your phone and ordering something from Walmart. Fifteen minutes later, a drone hovers over your yard, lowers your order down to you, and zips away. Adam Woodworth wants this to be so boring you don't even notice. He’s the CEO of Wing, a drone delivery company. His problem is this: How do you turn a flashy idea like a delivery drone into something as ubiquitous as a shopping cart? See omnystudio.com/listener for privacy information.

Designing a Drone That Delivers

Psychedelics are going mainstream. The FDA has approved ketamine for certain patients with depression, and may soon approve MDMA for post-traumatic stress disorder (PTSD). But a fundamental question remains unclear: How do psychedelics work?
Gul Dolen is a professor of psychology and neuroscience at UC Berkeley. In a series of experiments, Gul has found evidence of a common mechanism that a wide range of psychedelics use to affect the brain. If Gul is correct, these drugs may be useful not only for people suffering from mental illness, but also for people dealing with neurological problems like strokes. See omnystudio.com/listener for privacy information.

Understanding Obesity and Alzheimer’s via Epigenomics

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